HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis

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HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis.

Infection with the human immunodeficiency virus-1 (HIV-1) and acquired immunodeficiency syndrome (AIDS) are often associated with severe and debilitating neurological problems that include behavioral abnormalities, motor dysfunction and frank dementia. HIV-1-infected peripheral immune cells, in particular macrophages, appear to infiltrate the CNS, release neurotoxins and provoke a neuropatholog...

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ژورنال

عنوان ژورنال: Frontiers in Bioscience

سال: 2008

ISSN: 1093-9946,1093-4715

DOI: 10.2741/2860